Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans FRANK ZERBIB,1 STANISLAS BRULEY DES VARANNES,1 CARMELO SCARPIGNATO,1,4 VÉRONIQUE LERAY,1 MASSIMO D’AMATO,2 CLAUDE ROZÉ,3 AND JEAN-PAUL GALMICHE1
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چکیده
FRANK ZERBIB,1 STANISLAS BRULEY DES VARANNES,1 CARMELO SCARPIGNATO,1,4 VÉRONIQUE LERAY,1 MASSIMO D’AMATO,2 CLAUDE ROZÉ,3 AND JEAN-PAUL GALMICHE1 1Human Nutrition Research Center and Department of Gastroenterology and Hepatology, University of Nantes, 44035 Nantes; and 3Institut National de la Santé et de la Recherche Médicale U-140, Faculté X. Bichat, 75870 Paris, France; 2Rotta Research Laboratorium, 2052 Monza; and 4Department of Internal Medicine, University of Parma, 43100 Parma, Italy
منابع مشابه
Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans.
Transient lower esophageal sphincter (LES) relaxations (TLESRs) are the main underlying mechanism of gastroesophageal reflux. Although CCK acts through CCK-A receptors to increase the TLESRs induced by gastric distension, the respective roles of endogenous CCK and fundic tone in triggering postprandial TLESRs remain unknown. The aim of this study was to determine the effect of the CCK-A recepto...
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